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Instill Science / post-vc4NiuBN
May 5, 2023jessica-sacher
CRISPR Phage therapy

Y. Emre Gencay and colleagues have developed engineered phages with CRISPR-Cas machinery to reduce E. coli in mice. The phages, called SNIPR001, were well tolerated in mouse models and minipigs, and out-competed their ancestral wild-type phages in coculture experiments. SNIPR001 is in clinical development and may benefit hematological cancer patients.

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