October 12, 2023 ∙ jessica-sacher
Phage-Antibiotic Synergy
Cell Filamentation
Instill Science
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Instill Science / post-MCJtizGg
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jon-dennis
∙ October 17, 2023
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Interestingly, this was shown in our prior pub: Burkholderia cepacia complex Phage-Antibiotic Synergy (PAS): antibiotics stimulate lytic phage activity.
Kamal F, Dennis JJ. Appl Environ Microbiol. 2015 Feb;81(3):1132-8. doi: 10.1128/AEM.02850-14.
And, we comment of PAs mech of action in this Pub: Aztreonam Lysine Increases the Activity of Phages E79 and phiKZ against Pseudomonas aeruginosa PA01.
Davis CM, McCutcheon JG, Dennis JJ. Microorganisms. 2021 Jan 12;9(1):152. doi: 10.3390/microorganisms9010152.
But neither of these were referenced in this manuscript.
I wonder why?
Julián Bulssico (Aix-Marseille Université) and colleagues have discovered that cell filamentation plays a key role in successful phage predation, leading to phage-antibiotic synergy.