Instill Science

A place to discuss science, share work, and find mentors and collaborators

Instill Science / Phage therapy: From biological mechanisms to future directions
January 17, 2023atif-khan
Phage therapy: From biological mechanisms to future
Phage therapy Therapeutic phages Synthetic phages

Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) preferably be lytic, (2) kill the bacterial host efficiently, and (3) be fully characterized to exclude side effects. Developing therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review the state of the art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, and future directions involving naturally occurring and genetically modified or synthetic phages.

Loading ...
No comments yet. Be the first to comment!